Weight loss & metabolic peptides
The highest-intent category: GLP-1 and GLP-1/GIP agonists for appetite and glycemic control, plus Tesamorelin for visceral fat. These are the peptides patients most often arrive already asking for by name.
| Structure | Compound | What it does | How it's taken | Standing | Can I get it? |
|---|---|---|---|---|---|
| AOD-9604 hGH(176–191) fragment | A 16-amino-acid piece of growth hormone built to burn fat without hGH's baggage. | Injection Oral | Not FDA-approved · no US pharmacy route | None verified yet | |
| Tesamorelin GHRH analog | The only FDA-approved GHRH analog, originally cleared for HIV-associated lipodystrophy and now used off-label for visceral fat reduction, metabolic health, and cognitive support. | Injection | FDA-approved for HIV lipodystrophy | None verified yet | |
| Semaglutide GLP-1 receptor agonist | A once-weekly GLP-1 receptor agonist that reduces appetite, slows digestion, and supports meaningful weight loss in patients with obesity or overweight plus comorbidities. | Injection Oral | FDA-approved | Available · from $126/mo | |
| Tirzepatide GLP-1 / GIP receptor agonist | A dual GIP/GLP-1 receptor agonist delivering weight loss in the range of bariatric surgery's lower band — weekly, subcutaneously, with side effects that are mostly transient. | Injection | FDA-approved | Available · from $199/mo | |
| GLP-1 agonists Incretin drug class | The drug class that reshaped metabolic medicine — from glucose control to cardiovascular protection to weight loss in the surgical range. | Injection Oral | FDA-approved drug class | Available · from $126/mo | |
| Retatrutide GLP-1 / GIP / glucagon agonist | An investigational triple agonist from Eli Lilly that produced the largest weight loss any obesity drug has reported in trials — and that no US pharmacy can legally supply. | Injection | Not FDA-approved · no US pharmacy route | None verified yet | |
| Liraglutide GLP-1 agonist (daily) | The first GLP-1 receptor agonist to prove cardiovascular benefit in a randomized trial, now available as Victoza for type 2 diabetes and Saxenda for chronic weight management. | Injection | FDA-approved | Available · from $179/mo |
How you get it differs by row, and the standing chip says which: a retail pharmacy where a branded form exists, a compounding pharmacy on a clinician's prescription for most of the rest, and no lawful US supply at all where the chip says there is no pharmacy route. What the research shows, and what it does not, is on each guide.
4 of 7 have a verified provider · from about $126/mo
Every headline price in this market excludes something, so each guide carries the providers for its own compound with the figure normalized to a calendar month and the exclusion spelled out. ProviderMatch does the same across all of them at once.
From consult to results
- 01 Consult A licensed provider reviews your goal, history, and labs before any protocol is offered.
- 02 Protocol If appropriate, a compounding pharmacy prepares the peptide; your provider sets dose and duration.
- 03 What changes Response windows vary by peptide and by person. Each peptide page states what the published evidence reports.
Questions about weight loss & metabolic peptides
Are weight loss & metabolic peptides FDA-approved?
Status varies by compound and is described per peptide on its own page. Most are dispensed as compounded preparations rather than FDA-approved products.
Do I need a prescription?
Yes. These are obtained through a licensed provider and a compounding pharmacy.
How long until I notice anything?
Onset varies by peptide — each peptide page gives what the studies report.
How do I find a provider?
Open ProviderMatch: it shows which providers sell the compound for your goal, what each one charges to start, and what they publish about your state.
The complete Weight Loss & Metabolic guide
We publish no medical reviewer by design. Our partner hub PeptideWellness maintains the continuously-updated weight loss & metabolic reference — every covered peptide, the published research, dosing detail and provider notes, with citations.
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