# TB-500

> Source: https://peptidestogo.com/peptides/tb-500/
> Last updated November 2, 2026 · PeptidesToGo Editorial Team · Educational, not medical advice

Thymosin β4 fragment

**Status:** Not FDA-approved · compounded · Prescription only

**How it is delivered:** Injection — two to three times a week, then every two weeks.

TB-500 is a seven-amino-acid peptide — sequence Ac-LKKTETQ — lifted from positions 17 through 23 of thymosin beta-4, a protein found in nearly every nucleated cell in your body. Thymosin beta-4 is one of the most abundant intracellular proteins; it’s not exotic, it’s part of normal cell biology. TB-500 reproduces the actin-binding motif that drives much of the parent protein’s downstream activity.

The mechanism centers on cell migration and angiogenesis. TB-500 binds actin monomers and keeps them in a polymerization-ready pool, so when a cell needs to move — toward a wound, toward a damaged vessel — that buffered pool releases, actin polymerizes fast, and the cell migrates without having to synthesize new actin from scratch. It also promotes vessel formation through endothelial pathways and helps fibroblasts deposit collagen at the repair site. The practical implication: better-organized healing in places where blood supply is limited and repair is normally slow.

> “TB-500 is the structural complement to BPC-157 — where BPC works locally on tissue integrity, TB-500 works on the scaffolding that lets cells migrate and rebuild.”

Most of the evidence comes from preclinical and early research, with a small set of Phase II trials on the parent molecule (thymosin beta-4) in cardiac and wound indications. The fragment itself has minimal direct human trial data — the full study list and the evidence gaps live on our PeptideWellness deep-dive.

Last updated November 2, 2026 · PeptidesToGo Editorial Team ·
[Educational, not medical advice](https://peptidestogo.com/legal/medical-disclaimer/)

## Who it's for (or who should avoid)

### What it's aimed at

TB-500 protocols are most commonly prescribed for:

- **Tendon and ligament injuries** — rotator cuff strains, Achilles tendinopathy, chronic elbow issues, plantar fasciitis
- **Muscle strains and recovery** — training-induced microtrauma, post-injury repair
- **Post-surgical healing** — soft-tissue procedures where slow vascularization typically delays recovery
- **Joint pain** — particularly osteoarthritis-related shoulder and knee pain
- **Performance recovery** — athletes managing chronic overuse injuries

### Who should avoid it

- Anyone with active, recent, or suspected malignancy (or a strong family history) — TB-500 is pro-angiogenic, so an oncologist sign-off is the right step
- People subject to WADA or sport-organization testing — TB-500 is explicitly prohibited at all times
- Anyone pregnant, breastfeeding, or planning a pregnancy in the near term — no controlled human data
- Patients with pre-existing cardiovascular disease — discuss with a cardiologist before starting

> Real molecule, real biology, sold as a research chemical and banned in sport at all times. The science and the market it is sold in are not in the same place.

It makes the work your body is already doing more efficient — in animals, which is where nearly all of the evidence sits. There is no human trial establishing when a person would notice anything, so the stages below describe how it is used alongside structured rehab, not a schedule you should expect to hit.

## Route, dose and course

**Used for:** Systemic recovery and soft-tissue repair

**How it’s taken:** Subcutaneous or intramuscular injection. Some providers inject closer to the injury site for localized tendon or ligament issues.

**Doses sellers list:** Rx Peps Direct lists 2.5 mg per injection, no frequency given. CellGenic, a research-chemical seller, published 2–2.5 mg every other day (about 4–8 mg a week), then 2–6 mg a month, over a 12-week cycle; its live page no longer shows this. — No dose is approved for TB-500. We searched the sellers' own pages so you don't have to; the figures are theirs, not a recommendation. Your prescriber sets the dose. Where these figures come from: Rx Peps Direct peptide list (checked Oct 16, 2026) · CellGenic page, Wayback capture of 15 Feb 2026 (checked Oct 16, 2026)

**Cycle:** CellGenic's archived page: a 12-week cycle, a starting phase into maintenance. Rx Peps Direct publishes none. Where these figures come from: CellGenic page, Wayback capture of 15 Feb 2026 (checked Oct 16, 2026)

**Legal status:** Not FDA-approved and not on the 503A bulks list. Since October 28, 2026, HHS has said it will not act against licensed pharmacies that compound it for a named patient as a single ingredient, by subcutaneous or intramuscular injection only, under the conditions of its enforcement-discretion policy. Blends and research-use-only products are outside it. Prohibited in sport under WADA S2.

**What it costs:** About $165 a month — From the sellers' own pages on November 4, 2026; some sell it per vial or unit instead. Each figure, with what it leaves out, is in the table under “Can I actually get it?”. A vial buys a quantity, not a month.

TB-500 is prescribed as a subcutaneous or intramuscular injection. Some providers inject closer to the injury site (peri-tendinous) for localized tendon or ligament issues, particularly for Achilles and rotator cuff injuries.

What sellers publish (we checked on 16 October 2026):

- **Dose:** [Rx Peps Direct](https://www.rxpepsdirect.com/peptides) lists 2.5 mg per injection and does not say how often
- **Phases:** [CellGenic](https://web.archive.org/web/20260215172915/https://cellgenic.com/product/tb-500-3/), a research-chemical seller, published 2–2.5 mg every other day (about 4–8 mg a week), then 2–6 mg a month, over a 12-week cycle; the page we link is the Wayback Machine capture of 15 February 2026, because the live page no longer shows it. No dose is approved for TB-500

## No measured timeline

No human trial has measured how soon TB-500 works or how long any effect lasts, and we found no source we trust for a week-by-week picture, so we do not draw one. Agree with your prescriber what you will measure and when you will check it.

## Available · from about $165/mo

Every headline price in this market excludes something. These are normalized to a
 calendar month, cheapest first, with the exclusion spelled out — the published figure
 is the footnote under it.

| Provider | From, per month | What that figure excludes | Coverage | Their own site |
| --- | --- | --- | --- | --- |
| [Live Vital](https://peptidestogo.com/providers/live-vital/) — Physician-led, monthly pricing, Draper UT | $165 (read 2026-11-04) | The dose the figure buys, which is not published; sold as a 2-month subscription, $329 every 2 months. | All 50, stated | [Go to site ↗](https://livevital.io/) |
| [Defy Medical](https://peptidestogo.com/providers/defy-medical/) — Tampa clinic, physician-led | No price for this compound | Peptides are priced per vial rather than per month, and neither the consultation nor the lab work that has to precede it is priced anywhere on the site. | Not published | [Go to site ↗](https://www.defymedical.com/) |
| PeRx — Peptide-only telehealth, Wellness MD Group PC | No price for this compound | The only peptide figure on the site is a floor for the whole menu — treatment plans "starting at $199" — so there is no price for any individual compound. The provider review is included; there is no separate consultation fee. | All 50, stated | [Go to site ↗](https://www.perxpeptides.com/) |
| [RxPepsDirect](https://peptidestogo.com/providers/rxpepsdirect/) — Per-vial prices, 503A pharmacy in Texas | $80 per vial (read 2026-11-04) | The $39 telehealth visit, charged per order. | A named list | [Go to site ↗](https://rxpepsdirect.com/) |

### Will it work where you live?

Most sellers claim all fifty states or publish nothing about coverage; a few name
 the states they serve or the ones they exclude, and the Coverage column says which.
 Either way it is the seller's own claim, so we can't filter this list by state
 without inventing a fact. What we can tell you is which state-level rules decide
 access: telehealth rules, non-resident pharmacy licensing, and who is allowed to
 prescribe.

[What shapes access in your state →](https://peptidestogo.com/tools/state-checker/)

### Prices and providers change. We keep track.

## Questions we get about TB-500

### Is TB-500 FDA-approved?

No — TB-500 is not an FDA-approved drug and isn't sold at retail pharmacies. There is no approved label for it to be prescribed off; licensed clinicians prescribe it and compounding pharmacies prepare it. TB-500 is on no 503A category list that permits standard compounding. On July 23, 2026 the FDA's Pharmacy Compounding Advisory Committee reviewed it for wound healing: the agency proposed leaving it off the 503A Bulks List, and the committee voted 8–6–1 to recommend adding it. A committee recommendation is not the rule itself — the FDA has to write that — so confirm current compounding access with your provider.

### Is it legal?

Compounding it on a prescription is now tolerated, under conditions, though it is still on no list that authorises it. Section 503A lets a pharmacy compound only from an ingredient of an FDA-approved drug, a substance with a USP monograph or one on the FDA's 503A bulks list, and TB-500 is none of these. On October 28, 2026, HHS said it will not take action against State-licensed pharmacies and licensed physicians that compound TB-500 for a named patient while the FDA decides whether to list it. The conditions: TB-500 is the only active ingredient, the route is subcutaneous or intramuscular injection only, the bulk substance comes from an FDA-registered manufacturer named on a certificate of analysis, and serious side effects are reported to the FDA. HHS can withdraw the policy. A blend that mixes TB-500 with other peptides is outside it, and buying from "research chemical" sellers without a prescription is still not a lawful supply route for human use. Since November 2, 2026, LegitScript, the certifier whose seal many telehealth sites show, no longer refuses certification to sellers whose TB-500 meets these conditions; that seal is not FDA approval.

### Are there side effects?

In published work on the parent molecule (thymosin beta-4), reported side effects were typically mild: injection-site irritation, transient headache. Serious adverse events were rare in Phase I and Phase II trials. TB-500 itself has minimal direct human trial data, so the safety profile is extrapolated from the parent molecule. As with any prescription, discuss your full medical history with your provider before starting.

### Can I take it with my current medications?

There is no interaction data. Thymosin beta-4, the full protein TB-500 is a fragment of, has a mild safety profile, but that does not transfer to the fragment, and no long-term toxicity data exists for either. Always disclose your full medication list — including supplements — to your provider.

### How much does it cost?

In the price table on this page, the monthly figure is about $165, read on November 4, 2026. Some sellers price it per vial or unit instead, shown in the same table. PeRx sells it only inside blends. It sits in the same holding pattern as BPC-157: recommended for the compounding list by an FDA advisory committee in July 2026, not yet acted on. What moves your number is the dose, the vial size the pharmacy fills, and how long a plan you sign. Ask for it in writing up front. Insurance does not cover it.

### How is TB-500 different from BPC-157?

They work differently: BPC-157 promotes new blood-vessel growth through nitric oxide, and TB-500 is a fragment of thymosin beta-4 that helps cells migrate to an injury. Neither is FDA-approved. BPC-157 has a small amount of human research; for the TB-500 fragment itself there is almost none, and most of the data belongs to its parent protein. Taking them together rests on theory, not trials. An FDA advisory committee recommended both for the compounding list in July 2026, and the FDA has not acted. HHS's October 2026 policy tolerates compounding each one on its own; a premixed BPC-157/TB-500 vial is outside it.

We publish no medical reviewer by design. Every claim on this page traces to a
 source we hold on file, and the reviewed write-up with those citations lives on our
 hub.
[Read the full research on PeptideWellness ↗](https://peptidewellnessusa.com/peptides/tb-500/)

## Commonly stacked with

## Related peptides